Treatment Study of Vitamin D Deficiency in Adolescents
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
To compare the efficacy of two high dose vitamin D3 regimens (5,000 IU daily vs. 50,000 IU
weekly) used clinically for the treatment of vitamin D deficiency versus a low dose of
vitamin D3 used for supplementation (1,000 IU daily) in a clinical sample of predominantly
Hispanic and black adolescents with vitamin D deficiency [25(OH)D level <20 ng/ml] by
assessing change in 25(OH)D levels before and after 8 weeks of treatment.
To compare the effects of vitamin D repletion [25(OH)D level >20 ng/mL] on selected
musculoskeletal, cardiometabolic and immune markers in predominantly Hispanic and black
adolescents with vitamin D deficiency [25(OH)D level < 20 ng/mL].
Hypothesis 1: Increase in vitamin D level will be associated with improvement in
musculoskeletal, cardiometabolic, and immune markers including blood pressure, waist
circumference, musculoskeletal symptoms, asthma severity and hand-grip strength.
Phase:
Phase 4
Details
Lead Sponsor:
Montefiore Medical Center
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins