Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coord/Data Mgmt Site
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
The aim of this project is to conduct a multi-site effectiveness study to determine whether
the addition of a monthly injection of depot naltrexone to treatment as usual (TAU) will
significantly improve outcome in parolees and probationers with a history of opioid addiction
compared to TAU alone. Participants will be randomized to either treatment as usual in
community programs or monthly injections of depot naltrexone for six months with treatment as
usual in community programs. The effectiveness of depot naltrexone has never been studied in
opioid dependent parolees. all parolee subjects will be evaluated at baseline, while in
treatment, and at 6, 12 and 18 month post entry time points. The primary study outcomes are
retention in treatment, drug use, re-arrests, psychosocial and medical/psychiatric
functioning, and economic costs and benefit costs of naltrexone.