Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Hypertension is a leading cause of morbidity and mortality globally. Although multiple drugs
are frequently used to treat it, in the South Asian context, evidence is lacking on best drug
combinations. This trial aims to compare efficacy of three single-pill combinations of two
anti-hypertensive agents on 24-hour ambulatory systolic blood pressure among 1968 individuals
with hypertension. The trial is a single-blind randomized controlled trial spread across 15
hospitals in India.
Single Pill combinations (SPCs): 1) Amlodipine + Perindopril, 2) Perindopril + Indapamide, 3)
Amlodipine + Indapamide
Phase:
Phase 4
Details
Lead Sponsor:
Centre for Chronic Disease Control, India
Collaborators:
All India Institute of Medical Sciences, New Delhi Imperial College London
Treatments:
Amlodipine Indapamide Indapamide, perindopril drug combination Perindopril