Treatment Intensification With Temozolomide in Adults With a Glioblastoma
Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
Due to conflicting data on the optimal moment to start TMZ chemotherapy and the impact of
prolongation of the adjuvant phase with TMZ, the ANOCEF (Association des Neuro-Oncologues
d'Expression Francophone) group proposes this randomized trial comparing an intensified arm
(early TMZ and extended adjuvant TMZ until toxicity, progression or patient refusal) versus
the classical EORTC regimen as control (RT and concomitant TMZ started 4-6 weeks after
surgery followed by a number of adjuvant TMZ cycles strictly limited to 6) for primary GBM
adult patients.
Phase:
Phase 3
Details
Lead Sponsor:
Centre Oscar Lambret
Collaborators:
Association de Neuro-Oncologues d'Expression Francaise Association de Neuro-Oncologues d’Expression Francaise Erasme University Hospital