Treatment Efficacy of Corticosteroids, Mycophenolate Mofetil and Tacrolimus in Patients With Immune Related Hepatitis

• Status: Not yet recruiting
• Trial end date: 2023-11-07

Summary

This clinical trial is to clarify and investigate the patterns of immune related hepatitis and the optimal treatment choice for patients who are refractory to steroids. The project aims to prospectively characterize the various histopathological, biochemical and phenotypical liver injury patterns induced by immune checkpoint inhibitors, and the response to treatment to corticosteroids. Furthermore, the effect of adding a second-line immunosuppressive drug, either MMF or tacrolimus in steroid refractory or steroid dependent cases will be explored and compared.

• Phase: Phase 2

Details

• Lead Sponsor: Inge Marie Svane
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Mycophenolic Acid; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Tacrolimus; Ursodeoxycholic Acid