Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients
Status:
Completed
Trial end date:
2003-10-01
Target enrollment:
Participant gender:
Summary
This study aims to determine if treatment with an SSRI antidepressant medication, paroxetine,
is associated with cellular calcium response to serotonin, platelet serotonin receptors, and
improvement in mood in depressed patients with or without hypertension. It is hypothesized
that platelets of hypertensive patients with depressive symptomatology with be
hyper-responsive to serotonin. Additionally, treatment with an SSRI antidepressant is
expected to produce a down-regulation of the serotonin receptor with an associated reduction
in platelet cytosolic calcium response as well as improved mood.
Phase:
Phase 4
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development