Treatment Effects of Atorvastatin on Hemostasis and Skin Microcirculation in Patients With Type 1 Diabetes
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
Patients with type 1 diabetes are at increased risk of vascular complications both in the
micro- and macrocirculation. Hyperglycemia plays a major role in the development of these
vascular complications, but other factors such increased platelet adhesion and aggregation,
elevated levels of plasma fibrinogen, altered fibrin network structure, increased thrombin
generation, dyslipidemia and endothelial dysfunction may contribute.
Lipid-lowering therapy with statins is effective in prevention of cardiovascular events in
individuals at increased risk. Statins seem to exert beneficial effects on hemostasis and
vasculature that are independent of their lipid-lowering properties.
The aim of the present study was to investigated the effects of intensive
LDL-cholesterol-lowering therapy with atorvastatin on fibrin network permeability (primary
variable) and other aspects of hemostasis in patients with type 1 diabetes and dyslipidemia.
Furthermore, the effects of atorvastatin therapy on skin microvascular function was also
investigated.