Treating the Endothelium to Restore Insulin Sensitivity

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indiana University School of Medicine
• Treatments: Insulin; Losartan

Criteria

Inclusion Criteria:

• Healthy

• Age 20-55

• Male and female

• Obese, defined as Males: BMI >28 or > 30% fat by DEXA scan or Bod Pod; Females: BMI >30 or > 33% fat by DEXA scan or Bod Pod

• Weight stable over at least 4 months

Exclusion Criteria:

• Diabetes mellitus (ADA criteria)

• Age <20 or > 55 yrs

• Blood pressure >160/90 or < 90/65 mmHg

• Total cholesterol >240 or LDL cholesterol >160 mg/dL

• Baseline elevations in AST or ALT > 3X ULN

• Baseline elevation in creatinine >1.6 ng/mL

• Unexplained baseline elevation in creatine kinase > 3X ULN

• Concurrent significant chronic medical illness including, but not limited to, human immunodeficiency virus infection, Syphilis, hepatitis B infection, or hepatitis C infection

• Pregnancy

• Known hypersensitivity or intolerance to the study agents