Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine whether dialectical behavior therapy and fluoxetine are more effective combined or alone in treating people with borderline personality disorder.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New York State Psychiatric Institute
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Fluoxetine

Criteria

Inclusion Criteria:

• Meets criteria for diagnosis of borderline personality disorder

• History of at least one suicide attempt or self-mutilation episode 12 months prior to study entry

• Experiences continued urges to self-mutilate or attempt suicide

• Stable living situation

• Use of effective birth control if sexually active

• Clinically stable enough to tolerate placebo condition

• Not participating in other forms of treatment during the study

Exclusion Criteria:

• Any current organic mental syndromes, lifetime schizophrenic or bipolar disorders, psychotic disorders, or mental retardation

• Inability to complete psychiatric interview due to lack of cooperation or lack of comprehension

• Unable to tolerate fluoxetine or DBT

• Currently receiving treatment for an acute medical illness or other debilitating problem, including substance abuse or anorexia nervosa

• History of major depression lasting more than 3 months

• Current Hamilton depression score above 22 and not receiving treatment

• Pregnant or breastfeeding