Overview

Treating Postictal Symptoms Using Ibuprofen and Nifedipine

Status:
Recruiting
Trial end date:
2025-03-01
Target enrollment:
0
Participant gender:
All
Summary
This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy. One group will receive ibuprofen, another will receive nifedipine, and anther placebo.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Calgary
Treatments:
Ibuprofen
Nifedipine
Criteria
Inclusion Criteria:

- age > 16 yrs, frequent seizures (>1 per week) and cognitive ability sufficient to
complete neuropsychological testing.

Exclusion Criteria:

- multiple seizure onset zones, contraindications to CT or MR imaging, any
contraindication to ibuprofen or nifedipine, as well as current or recent (< 2 months)
exposure COX-2 inhibitor or calcium channel blocker.