Trastuzumab and Letrozole in Treating Postmenopausal Women With Progressive Advanced Breast Cancer
Status:
Completed
Trial end date:
2011-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Monoclonal antibodies, such as trastuzumab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Estrogen can cause the growth of
breast cancer cells. Hormone therapy using letrozole may fight breast cancer by lowering the
amount of estrogen the body makes. Giving trastuzumab together with letrozole after disease
progression may be an effective treatment for breast cancer.
PURPOSE: This phase II trial is studying how well giving trastuzumab together with letrozole
works in treating postmenopausal women with progressive advanced breast cancer.