Transversus Abdominis Plane Blocks With and Without Dexamethasone

• Status: Not yet recruiting
• Trial end date: 2023-03-31
• Target enrollment: 0
• Participant gender: All

Summary

Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Saskatchewan
• Treatments: Dexamethasone

Criteria

Inclusion Criteria:

• age > 18

• ASA class I-III

• elective or urgent inpatient laparoscopic/laparoscopic assisted colorectal surgery.

Exclusion Criteria:

• emergency surgery

• open surgery

• contraindications to laparoscopic surgery (ie. adhesions, inability to tolerate pneumoperitoneum)

• ASA class 4

• age < 18

• pregnant or breastfeeding women

• significant cardiorespiratory/hepatic/renal disease

• allergy to any study drugs

• inability to consent

• inability to respond to pain assessments

• inability to use the patient-controlled analgesia device (PCA)

• preoperative chronic opioid use