Transverse Abdominis Plane Block for Anterior Approach Spine Surgery

• Status: Completed
• Trial end date: 2019-05-25
• Target enrollment: 0
• Participant gender: All

Summary

Therapeutic, prospective, randomized, double blind, placebo-controlled, in intention to treat, monocentric study to evaluate the analgesic efficacy of a bilateral TAP block after spine surgery with 24 hours morphine consumption

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rennes University Hospital
• Treatments: Anesthetics; Ropivacaine

Criteria

Inclusion Criteria:

• Patient with age above 18 years old

• Patients scheduled for spine surgery by anterior approach

• Patient who signed an informed consent form

Exclusion Criteria:

• Allergy to ropivacaine

• Weight < 50 kg

• Contra indication to TAP block : sepsis in the point of draining, bleeding disorder

• Contra indication to paracetamol: severe hepatic insufficiency

• Contra indication to ketoprofen: age ≥ 75 years, renal insufficiency, previous gastric ulcer, allergy

• Contra indication to nefopam: severe cardiac insufficiency, glaucoma, prostate hypertrophy, allergy

• Known allergy to active substance or at least to one excipient (propofol, paracetamol, morphine, remifentanil, cisatracurium)

• Allergy to fentanyl, atracurium, or benzin sulfonic acid derivative, to propacetamol

• Convulsions or previous convulsive disorder

• Severe respiratory insufficiency

• Abnormal hemostasis or anticoagulant treatment because of possible intramuscular injection

• Morphine intake 24 hours before surgery

• Chronic use of morphine, gabapentin, pregabalin

• Pregnancy or breastfeeding

• Patient unable to use Patient Controlled Analgesia (PCA) (old patient depends…)

• Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty