Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Patients who have received antibiotics and thereafter developed diarrhea are investigated for
presence of Clostridium difficile toxin. Primary treatment is given with oral
metronidazole/vancomycin. In case of relapse, secondary treatment is given with either
cultured gut microbiota rectally or oral vancomycin in sequence. In those cases where
secondary treatment with vancomycin fails cultured gut microbiota is given as final
treatment. As an extension treatment, all failures were treated with cluttered gut microbiota
through the upper route. In both cases As an alternative cultured gut microbiota may be given
via the duodenal route. Follow-up is carried out after 7, 30 and 90 days with interview and
stool collection for analysis of Clostridium difficile.