Translocator Protein and Inflammation After Traumatic Brain Injury
Status:
Completed
Trial end date:
2017-09-28
Target enrollment:
Participant gender:
Summary
Background:
- People with traumatic brain injury (TBI) often have inflammation in the brain. A protein
called the translocator protein (TSPO) is often present with inflammation. Researchers want
to see if a radioactive chemical known as [11C]PBR28 can be used to study TSPO and
inflammation in the brain of people with TBI.
Objectives:
- To test whether [11C]PBR28 can be used to study changes in the brain after a traumatic
brain injury.
Eligibility:
- Individuals at least 18 years of age who have had TBI and have had a brain scan that
shows signs of inflammation.
- Healthy volunteers at least 18 years of age.
Design:
- Participants will be screened with a physical exam and medical history. Blood and urine
samples will be collected.
- All participants will have two brain scans during an outpatient visit. A magnetic
resonance imaging scan will study brain activity. A positron emission tomography (PET)
scan will use [11C]PBR28 to look for signs of TSPO and brain inflammation.
- Participants with TBI will have two PET scans within 10 days of the head injury, and a
PET scan around 90 days after the injury. They may also have MRI scans under this or
another study. Tests of thinking, memory, and concentration will be used to study the
effects of the injury and inflammation
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
National Institute of Mental Health (NIMH)
Collaborators:
Suburban Hospital Uniformed Services University of the Health Sciences