Transfusion-Associated Circulatory Overload Best Eliminated With Lasix
Status:
Completed
Trial end date:
2017-04-15
Target enrollment:
Participant gender:
Summary
This is a pilot double-blinded placebo-controlled randomized controlled trial (RCT) to
evaluate the feasibility of conducting a multicenter, randomized, placebo-controlled trial to
assess the efficacy of pre-transfusion furosemide in preventing transfusion-associated
circulatory overload (TACO) in hemodynamically stable inpatients aged 65 years or older
receiving a single unit red blood cell transfusion. Patients will be randomly allocated to
receive either furosemide (20mg intravenous) or placebo (saline) within 60 minutes of
starting a red blood cell (RBC) transfusion. Randomization will be stratified by centre and
renal dysfunction (creatinine clearance ≥ 60 mL/min or < 60 mL/min). This is a blinded trial:
patients, care-providers (physicians and nurses), data collectors, outcome adjudicators, and
data analysts will not be aware of group allocation.
Phase:
Early Phase 1
Details
Lead Sponsor:
Sunnybrook Health Sciences Centre
Collaborators:
Canadian Blood Services University Health Network, Toronto