Transforaminal Epidural Platelet Rich Plasma Versus Epidural Steroid Injection for Lumbosacral Radicular Pain
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Lumbosacral radicular pain is present in around 40% of cases of low back pain. It is usually
caused by irritation and inflammation of the nerve root, and patients typically experience
pain radiating from the back to the lower limb in the distribution of the affected spinal
nerves. Epidural steroid injection is the most commonly used pain-relieving procedure in the
world. However, the analgesic efficacy of epidural steroid injection appears to be modest and
duration limited. Platelet rich plasma (PRP) is an emerging treatment option for chronic
pain. It is currently used for treating musculoskeletal pain conditions such as
osteoarthritis and tendinopathies. While epidural steroids reduce pain by reducing
inflammation, PRP promotes the healing of nerve injury and reduces neuropathic pain. However,
the effect of transforaminal epidural PRP versus epidural steroid specifically for
lumbosacral radicular pain is unclear. In this study, a double blind, randomized controlled
trial will be performed to compare the effect of transforaminal epidural PRP versus epidural
steroid for pain relief in patients with lumbosacral radicular pain.