A single arm, prospective multicenter non-randomized pivotal clinical trial evaluating the
Edwards SAPIEN XT™ transcatheter heart valve (model 9300TFX), NovaFlex™ transfemoral
delivery system, Ascendra2™ transapical delivery system and crimper accessories. The trial
includes a premarket pivotal cohort to evaluate the system performance as well as a post
market clinical follow-up phase involving long term follow-up of all patients to evaluate
the safety of investigational devices up to 5 years.