Transcriptomic Study of ER 4017 Topical Application in Elderly Subject
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
The stratum corneum (SC) is the superficial layer of the epidermis situated at the interface
between the body and its outside environment. Its strategic position confers it a crucial
role of protection against aggressions. After disruption, the kinetic of cutaneous barrier is
slower in elderly comparatively to young subjects.
The purpose of this study is to investigate, by characterizing molecular events, the
effectiveness of ER4017 (Hydroxypropyltetrahydropyrantriol) to restore kinetic barrier
function after acute disruption of stratum corneum in ederly subjects.
10 male volunteers aged from 60 to 75 years are randomized to receive topical application of
ER4017 versus placebo on skin inner forearms twice a day during 3 months. After sequential
selloptape strips, epidermal samples of treated and control skin are removed under local
anesthesia, using a dermatome. Differential gene expression analysis is performed using micro
array techniques and quantitative RT-PCR.
treatment, randomized on the location, double blind, placebo control, internal control
subject, prospective study.