Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)
Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
This study is designed to assess if there is a significant difference in same day discharge
rates after Holmium Laser Enucleation of the Prostate (HoLEP). The investigators attempt to
perform HoLEP as a same-day discharge (SDD) procedure, but at Northwestern Memorial, the SDD
rate is currently approximately 60%. The limiting factor in SDD is hematuria. Tranexamic acid
(TXA) is a clot promoting drug that is commonly used by orthopedic, cardiac and obstetric
surgeons to prevent bleeding. The primary outcome will be to assess if there is a difference
in SDD rates in those who receive TXA vs. those who do not.
Secondary outcomes will assess bleeding complications (defined as unplanned ED visit/clinic
visit/procedure/admission related to bleeding, clot retention, clot evacuation, need for
perioperative transfusion) between participants who receive TXA vs. those do not. The study
will also assess differences in perioperative complications associated with TXA including but
not limited to: deep venous thrombosis, pulmonary embolism, cerebrovascular events, between
the groups. The study will also assess for the duration of postoperative hematuria between
groups as well as differences in operative times between the groups.
The investigators anticipate that there may be up to a 25% increase in SDD rates in those who
receive TXA vs. those who do not.