This prospective randomized double-blind placebo vs control study aims at verifying the
efficacy of tranexamic acid administration in reducing perioperative bleeding in patients
undergoing open radical prostatectomy. Two recent meta-analysis confirmed that tranexamic
acid administration does not increase mortality, myocardial infarction, deep venous
thrombosis, pulmonary embolism, stroke and renal failure.
200 patients undergoing open radical prostatectomy will be enrolled. Patients will receive a
slow endovenous infusion of 500 mg of tranexamic acid before surgical incision, followed by
250 mg/h of tranexamic acid by continuous infusion.
Patients belonging to the control group will receive the same volume of saline infusions.