Total knee joint replacement surgery can lead to significant blood loss, which can affect
recovery after surgery. Tranexamic acid (TXA) is a medication which stops the breakdown of
blood clots and therefore prevents blood loss. The optimal use of TXA remains a point of
debate. Growing interest in the topical application of TXA (directly into the surgical wound)
has been suggested as an alternative way of administering TXA, and may demonstrate similar
effectiveness as when it is given intravenously. Therefore, this multicentred, randomized
controlled trial, aims to investigate the safety and effectiveness of both topical and
intravenous administrations of TXA in total knee joint surgery. The investigators predict
that both routes of administration will demonstrate similar results when compared to placebo.
Phase:
Phase 4
Details
Lead Sponsor:
Andrew G Hill Andrew G Hill, MBChB, MD (Thesis), EdD, FACS, FRACS