Tranexamic Acid for Preventing Progressive Intracranial Haemorrhage in Traumatic Brain Injury

• Status: Completed
• Trial end date: 2009-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The study's objective is to evaluate the effectiveness and safety of tranexamic acid for adult patients with moderate to severe TBI.With the research question as "Does TXA reduce the incidence of progressive intracranial haemorrhage by 50% compared to placebo in moderate to severe adult TBI patients at Khon Kaen Hospital?"

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Khon Kaen University
• Collaborators: Khon Kaen Hospital; Thailand Research Fund
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• moderate to severe injuries(post-resuscitation scores GCS 4-12)

• age >= 16 year

• non-penetrating TBI in 8 hours onset

• first CT brain in 8 hours onset

• non neurosurgical OR in 8 hours onset

Exclusion Criteria:

• patients with coagulopathy

• serum creatinine over than 2 mg%

• with associated major organ injury requiring surgery within 8 hours of injury

• pregnancy

• receiving any medication which affects haemostasis