Tranexamic Acid, Hemorrhage and Transfusions After Combined Aortic Valve Replacement and Coronary Artery Bypass Surgery.
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
In this study we will investigate whether tranexamic acid given as an intravenous bolus
injection before start of surgery, followed by a continuous infusion during surgery reduces,
perioperative hemostatic activation, and postoperative bleeding and the need for transfusions
of blood components in elderly patients undergoing combined aortic valve replacement and
coronary artery bypass surgery. Tranexamic acid will be compared with placebo (0.9% sodium
chloride) in a randomized and double-blind study design.
The study hypothesis is that tranexamic acid will reduce hemostatic activation and
postoperative hemorrhage and the need for blood component transfusions in this group of
patients.