Tranexamic Acid Effect on Digit Function Following Primary Repair of Traumatic Digit Flexor Tendon Injuries

• Status: Not yet recruiting
• Trial end date: 2023-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the effect of pre-operative treatment with IV Tranexamic Acid on post-operative digit function, in patients that underwent surgical repair of traumatic zone 1 or zone 2 digit flexor tendon tear.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rabin Medical Center
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• Patients that will undergo surgical repair of traumatic zone 1 or zone 2 digit flexor tendon tears

Exclusion Criteria:

• Age < 18

• Pregnant Women

• Patients that presented 3 weeks or later after the injury

• Medical history positive for Rheumatic disease

• Current active treatment with anti-coagulation medications

• Injury to more than one finger

• Presence of a fracture in the affected finger

• Presence of a nerve injury in the affected finger that won't enable early use and activation in early rehabilitation protocol

• Mangled extremity injury, degloving injury or other soft tissue injuries that won't enable primary closure of skin

• Previous tear of the affected tendon

• Degenerative tear of flexor tendon

• Tendon tear secondary to infection

• Previous injuries to contralateral side causing dysfunction and/or decreased fingers' range of motion

• Contraindications to Tranexamic acid treatment:

• Known hypersensitivity to tranexamic acid or to any other ingredient of the preparation.

• Patients with thromboembolic disease.

• Patients with active intravascular clotting.

• Severe renal failure because of risk of accumulation.

• Patients with subarachnoid hemorrhage

• Patients with acquired defective color vision