Overview

Tranexamic Acid Administration Strategies in Cardiovascular Surgery: Goal-directed vs. Empirical Tranexamic Acid Administration

Status:
Not yet recruiting

Trial end date:
2024-12-31

Target enrollment:

Participant gender:

Summary

The study's primary objective is to compare the amounts of postoperative bleeding using two different TXA administration strategies: empirical TXA administration vs. viscoelastic test-based goal-directed TXA administration in cardiovascular surgery. The secondary objectives include comparing the incidents of hyper-fibrinolysis, thromboembolic complications, and postoperative seizures. Researchers assumed that goal-directed tranexamic acid (TXA) administration using viscoelastic field tests would not be inferior to the empirical TXA administration strategy in reducing postoperative bleeding and hyper-fibrinolysis. It also would be beneficial in reducing TXA-induced thromboembolic complications and seizures.

Phase:

Phase 4

Details

Lead Sponsor:

Konkuk University Medical Center

Collaborators:

Asan Medical Center
Helptrial
Korea Health Industry Development Institute
Samsung Medical Center

Treatments:

Tranexamic Acid