Total Intravenous Anesthesia in Sinus Surgery

• Status: Completed
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Utilization of total intravenous anesthesia (TIVA) has been proposed as a method to improve visualization during endoscopic sinus surgery (ESS), largely due to its physiologic decrease in cardiac output without the peripheral smooth muscle relaxation and resultant vasodilation associated with inhaled anesthetics. This may be especially important in cases of advanced inflammatory sinus disease, when visualization may be most compromised. The goal of this study is to improve clinical practice paradigms by evaluating the use of TIVA versus inhaled anesthetic for maintenance of anesthesia in ESS for advanced paranasal sinus disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ochsner Health System
• Treatments: Anesthetics; Isoflurane; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Patients undergoing endoscopic sinus surgery

• Advanced inflammatory sinus disease, defined as allergic fungal sinusitis, chronic rhinosinusitis with nasal polyposis, chronic rhinosinusitis with eosinophilia, or rhinosinusitis with pan-sinus opacification (Lund-Mackay score >12).

Exclusion Criteria:

• Noninflammatory sinonasal disease

• Disease extending through the skull base or orbital wall

• American Society of Anesthesiologists Preoperative Health Status >II

• Known non-pharmacologic coagulopathy (platelet < 50000/mL, international normalized ratio > 1.2)

• Preoperative anticoagulants within 7 days of surgery

• Allergy to one of the study medications

• Age under 18 years

• Non-English-speaking