Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure

• Status: Recruiting
• Trial end date: 2024-08-14
• Target enrollment: 0
• Participant gender: All

Summary

The study is designed to be a prospective, randomized study is to compare the effectiveness of two standard of care loop diuretics (furosemide versus torsemide) on clinical outcomes among patients currently on a stable dose of loop diuretics.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yale University
• Treatments: Furosemide; Torsemide

Criteria

Inclusion Criteria:

1. Patients with a diagnosis of heart failure and who have been on a stable dose of a diuretic for at least 30 days.

2. Plan for a daily outpatient oral loop diuretic regimen with anticipated need for long term loop diuretic use

3. ≥ 18 years of age

4. Signed informed consent

Exclusion Criteria:

1. End-stage renal disease requiring dialysis therapy

2. Inability or unwillingness to comply with the study requirements

3. History of heart transplant or actively listed for heart transplant

4. Implanted left ventricular assist device or implant anticipated <3 months

5. Pregnant or nursing women or women who are trying to conceive

6. Malignancy or other non-cardiac condition limiting life expectancy to <12 months

7. Known hypersensitivity to furosemide, torsemide, or related agents