Overview

Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma

Status:
Recruiting
Trial end date:
2028-04-01
Target enrollment:
0
Participant gender:
All
Summary
This is a phase 3, multicentre, randomised controlled trial to study the effectiveness and toxicity of PD-1 antibody Toripalimab combined with concurrent cisplatin chemoradiotherapy versus cisplatin concurrent chemoradiotherapy alone in treating patients with locoregionally recurrent nasopharyngeal carcinoma.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Cancer Hospital of Guangxi Medical University
Criteria
Inclusion Criteria:

1. Patients with newly histologically confirmed recurrent nasopharyngeal carcinoma, or
Two or more image examinations (MRI, and PET-CT) show the recurrent tumor

2. staged as rT3-4N0-1M0或rT1-4N2-3M0 (according to the 8th AJCC edition)

3. Satisfactory performance status: ECOG (Eastern Cooperative OncologyGroup) scale 0-1

4. Neutrophil ≥ 1.5×109 /L and PLT ≥4×109 /L and HGB ≥90 g/L

5. With normal liver function test (ALT、AST ≤ 2.5×ULN, TBIL≤ 1.5×ULN)

6. With normal renal function test ( creatinine clearance ≥60 ml/min)

7. sign an "informed consent form

8. Male and no pregnant female

Exclusion Criteria:

1. Age older than 65, or younger than 18 years old

2. Hepatitis B surface antigen (HBsAg) positive and HBV-DNA ≥200IU/ml, or 1000cps/ml.

3. Patients with positive HCV antibody.

4. Active, known or suspected autoimmune disease; Type I Diabetes, hypothyroidism those
only need hormone replacement therapy, and skin disease (leukoderma, psoriasis,
alopecia et al) who don't need systemic therapy can recruit.

5. History of interstitial lung disease

6. Equivalent dose more than prednisone 10mg/d or other immunosuppressive treatments
within 28 days prior to signing the informed consent.

7. Receive or will receive live vaccine within 30 days prior to signing the informed
consent.

8. Women of child-bearing potential who are pregnant or breastfeeding.

9. Suffered from malignant tumors, except the carcinoma in situ, papillary thyroid
carcinoma, or skin cancer (non- melanoma) within five years.

10. Hypersensitivity to macromolecular protein, or to any component of triplezumab.

11. HIV positive.

12. Severe, uncontrolled medical conditions and infections.

13. Other diseases which may influence the safety or compliance of the clinical trial,
such as heart failure with symptom, unstable angina, myocardial infarction, active
infections those need systemic therapy, mental illness, or their family and society
factors.