Topotecan, Cisplatin, and Radiation Therapy in Treating Patients With Advanced Cervical Cancer
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as topotecan and cisplatin, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Radiation therapy uses high energy x-rays to kill tumor cells. Internal radiation
uses radioactive material placed directly into or near a tumor to kill tumor cells. Topotecan
and cisplatin may make tumor cells more sensitive to radiation therapy. Giving topotecan and
cisplatin together with radiation therapy may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of topotecan when
given together with cisplatin and radiation therapy in treating patients with advanced
cervical cancer.