Overview

Topiramate for Binge Eating Disorder Among Adolescents

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
This is a study of topiramate to see whether topiramate decreases binge eating behavior among adolescents and young adults. The investigators did also checked whether topiramate affected cognitive function or not.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
The Zucker Hillside Hospital
Treatments:
Topiramate
Criteria
Inclusion Criteria:

Subjects (aged 12 to 23) were included if they

- Met the criteria of bulimia nervosa or eating disorder NOS with binge-eating behavior
in DSM-IV-TR,

- Had weight > or = 100th % of expected body weight for their age,

- Engaged in binge eating at least once a week for 9 out of the 12 weeks prior to the
study entry, and

- Were judged by a clinician to be stable enough to be treated for their psychiatric
condition as an outpatient (i.e, no acute suicidality, hallucination, unstable vital
signs or persistently abnormal laboratory results due to eating disorder).

Exclusion Criteria:

- Subjects whose psychotropic medications had been changed within 4 weeks prior to the
entry or who had started psychotherapy within 3 months prior to the entry were
excluded.

- Subjects were also excluded if they were taking carbonic anhydrase inhibitors,
carbamazepine, phenytoin, phenobarbital, valproic acid, evening primrose oil or oral
contraceptives.

- Other exclusion criteria were: history of substance use disorders within the 6 months
prior to study, IQ < or = 70, medical conditions causing weight loss (i.e.,
hyperthyroidism, diabetes mellitus type 1, malignancy) or that contra indicate
treatment with topiramate (nephrolithiasis or glaucoma), history of non response or
poor tolerance to topiramate in the past and history of non-adherence to medication
treatment.