Topical Versus Oral Metronidazole Following Excisional Haemorrhoidectomy

• Status: Completed
• Trial end date: 2020-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to determine if topical metronidazole reduces pain more than oral metronidazole following excisional haemorrhoidectomy. The trial will be a multi-centered, patient and investigator blinded superiority trial with two parallel groups and a primary outcome of pain scores during 14 days after surgery.

Group A will receive oral metronidazole and placebo cream. Group B will receive placebo tablets and topical metronidazole cream.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Auckland, New Zealand
• Treatments: Metronidazole

Criteria

Inclusion Criteria:

• All patients undergoing excisional haemorrhoidectomy

Exclusion Criteria:

• < 16 years of age

• Have a simultaneous operation other than excisional haemorrhoidectomy

• History of chronic pain

• Previous allergy/adverse reaction to metronidazole

• Patients unable to consent or complete data questionnaires due to cognitive impairment