Topical Vancomycin Over Sternal Edge in Cardiac Surgery
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical
application of vancomycin paste over sternum edge is safe and can reduce sternal wound
infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of
vancomycin mixed with 2 ml normal saline. Vancomycin paste as control or 2 ml normal saline
as placebo will be spread on sternal edge immediately after sternotomy and before sternal
closure. The safety of Vancomycin paste over sternum edge will be assessed according to
postoperative serum Vancomycin exposure and potential side effects such as renal toxicity or
bacterial resistance. Effect of topical Vancomycin on incidence of postoperative sternal
wound infection will be assessed on postoperative 7, 30, and 90 days.