Overview

Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty

Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
0
Participant gender:
All
Summary
This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Henry Ford Health System
Treatments:
Tranexamic Acid
Criteria
Inclusion Criteria:

- All adult patients over age eighteen

- Primary unilateral total knee arthroplasty at Henry Ford Hospital (Detroit, Michigan,
United States) and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan,
United States)

Exclusion Criteria:

- patient history of venous thromboembolic disease or coagulopathy

- use of anticoagulant medications within 7 days of surgery

- history of arterial embolic disease

- history of Class III or IV heart failure

- renal failure

- intraoperative cardiovascular, pulmonary, orthopaedic, or anesthetic complication (MI,
intraoperative fracture, vasopressor support, emergent intubation).