Overview

Topical Steroids & Bacterial Decolonization for Radiation Dermatitis

Status:
Not yet recruiting

Trial end date:
2025-02-01

Target enrollment:
0

Participant gender:
All

Summary

The purpose of this study is to determine whether bacterial decolonization of the nares and skin, topical steroid therapy, or a combination of the two regimens prior to treatment with radiotherapy (RT) for breast and head and neck cancer patients can prevent grade 2 or higher grade radiation dermatitis (RD) graded via the Common Terminology Criteria for Adverse Events (CTCAE) scale and improve quality of life.

Phase:

Phase 2

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Montefiore Medical Center

Treatments:

Mometasone Furoate

Criteria

Inclusion Criteria:

- Age greater than or equal to 18

- Diagnosis of a breast or head and neck cancer with plans for fractionated RT (greater
than or equal to 15 fractions in 40 Gy (Gray)) with curative intent, including
post-operative patients deemed eligible for RT by their surgeons and radiation
oncologists

Exclusion Criteria:

- Prior RT to the region of interest

- Existing dermatologic condition affecting the treatment area (eg: atopic dermatitis,
psoriasis, and non-healing wounds; known allergy to intervention therapies)