Topical Naloxone to Diagnose Ocular Pain

• Status: Recruiting
• Trial end date: 2022-04-16
• Target enrollment: 0
• Participant gender: All

Summary

Chronic ocular neuropathic pain may be misdiagnosed as dry eye disease. Our study aims to identify a population with previous monocular trauma and dry eye symptoms and differentiate neuropathic from dry eye pain using topical corneal naloxone hydrochloride.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seema Capoor
• Treatments: Naloxone

Criteria

Inclusion Criteria:

• monocular trauma

• dry eye disease diagnosis

Exclusion Criteria:

• any pathology that might contribute to ocular pain, including corneal surface ulcers, uveitis, or other chronic inflammatory processes

• any current corneal surface pathology

• history of bilateral ocular trauma

• currently taking any of the following medications: TCAs, opioids, gabapentin, SNRIs

• pregnant nor breastfeeding.