Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy
Status:
Completed
Trial end date:
2020-12-18
Target enrollment:
Participant gender:
Summary
Treatments for painful diabetic peripheral neuropathy (PDPN) are not very effective and have
multiple side effects. To find out if a menthol cream alone or with added mannitol treats
PDPN effectively, 90 participants with PDPN, after one month of observation, will receive
randomly assigned menthol cream or the same cream with mannitol added for 3 months with a
crossover for 3 additional months. At time 0, 1,4 and 7 months their BPI pain severity and
interference scores, DN4 scores, cream % effectiveness and side effects will be compared.