Overview

Topical Irrigation Therapy for CRS

Status:
Terminated

Trial end date:
2017-05-04

Target enrollment:
0

Participant gender:
All

Summary

The purpose of the study is to evaluate the physiologic response of quinine-saline irrigations for acute exacerbation of uncomplicated chronic rhinosinusitis following endoscopic sinus surgery. Subjects who have previously had functional endoscopic sinus surgery with acute exacerbation of chronic rhinosinusitis will be randomized to either a quinine-saline or saline-placebo arm. The investigators will measure baseline and follow-up clinical and quality-of-life outcomes for both arms, and then compare the groups at the end of the study period. The investigators' hypothesis is that the participants in the quinine sulfate arm will perform better on all measures as compared to the control arm.

Phase:

Phase 1/Phase 2

Accepts Healthy Volunteers?

Details

Lead Sponsor:

University of Pennsylvania

Treatments:

Quinine

Criteria

Inclusion Criteria:

1. Patients who have undergone Functional Endoscopic Sinus Surgery (FESS)

2. Purulent drainage on nasal endoscopy

3. Male or female subjects, 18 years of age or older

4. Patients seen at the Dept. of Otorhinolaryngology clinic at Hospital of the University
of Pennsylvania (HUP), a tertiary care clinic

Exclusion Criteria:

1. Pregnant women

2. Immunocompromised patients

3. Granulomatous diseases with rhinologic manifestations (Wegner's, Sarcoid,
Churg-Strauss)

4. Primary ciliary dyskinesia