Rationale: CBD is commonly being used as an over-the-counter treatment for arthritis-related
pain, however no clinical trial has been performed to establish efficacy.
Hypothesis: CBD is more effective than placebo for relieving pain and improving
patient-reported outcomes for thumb basal joint arthritis.
Study Design: The study design with be a double-blind, randomized controlled trial with
crossover. Treatment will be blinded to the subjects and investigators. Patients will be
randomly assigned 2 weeks of the CBD or control and then crossover to the other condition for
2 additional weeks. Patients will apply the cream at the thumb base twice daily for 1 hour.
Subjects will be advised to observe for physiologic changes, skin changes, or other adverse
effects.