Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus
Status:
Unknown status
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
Oral Lichen Planus (OLP) is an autoimmune, chronic inflammatory mucocutaneous disease
characterized by pain and burning sensation. The major types of OLP are the following:
reticular, atrophic, erosive-ulcerative, bullous and pigmentous form.Its etiology remains
unclear. The presence of auto-cytotoxic T cell clones in the lesions suggests the role of
autoimmunity. Numerous treatment options of OLP include topical and systemic agents depending
on severity of lesions . Topical corticosteroids abide the mainstay of therapy,and are widely
accepted as the primary treatment of choice.Hence this study is designed to evaluate and
compare the clinical efficacy of topical Clobetasol 0.05% in orabase and Betamethasone 0.05%
in orabase in combination with Clotrimazole 1% in the management of symptomatic Oral Lichen
Planus.