Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects
Status:
Completed
Trial end date:
2020-03-18
Target enrollment:
Participant gender:
Summary
Currently, topical antihistamines and corticosteroids are mainly used for itching relief.
However, the over the counter antihistamines are not effective on all itch conditions.
Acetaminophen is a popular and widely used OTC drug for pain relief. Although its mode of
action is still unknown, recent studies have shown that acetaminophen indirectly activates
cannabinoid CB1 receptors. Recent studies have shown that topical cannabinoid agonists are
effective for itch relief, the efficacy of topical acetaminophen will be tested for
non-histaminergic itch relief.