Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
25 patients who are diagnosed with Cytomegalovirus (CMV) anterior segment infection, either
uveitis or endotheliitis, will be started on 2% guttae ganciclovir, 1 drop 5 times a day for
6 weeks.
Following 6 weeks of continuous application of 2% guttae ganciclovir, patient will be
reviewed at the clinic within 3 hours following the last application of topical ganciclovir
and clinical features will be documented for activity assessment. An aqueous sample 0.2ml is
drawn. 0.1ml will be sent for RT-PCR for CMV viral load and another 0.1ml will be sent for
ganciclovir drug level by HPLC method.