Tolerability of Hypertonic Saline in Infants With Cystic Fibrosis

• Status: Completed
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study is to determine whether or not inhalation of hypertonic saline will be tolerated by infants with cystic fibrosis and the effect of inhalation on their lung function.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Hospital for Sick Children

Criteria

Inclusion Criteria:

• Confirmed diagnosis of cystic fibrosis

• Age 2 months to 2 years

• Routinely scheduled infant pulmonary function test.

• Clinical stability (no respirator tract infection for 4 weeks prior to study

Exclusion Criteria:

• Acute respiratory symptoms

• Wheezing at the time of study

• Supplemental oxygen therapy

• Oxygen saturation < 95 % on room air