Overview

Tolerability and Efficacy of High Dose Escitalopram for the Treatment of Obsessive-Compulsive Disorder (OCD)

Status:
Completed
Trial end date:
2006-12-01
Target enrollment:
0
Participant gender:
All
Summary
Objectives: To evaluate tolerability and efficacy of escitalopram treatment in high dose than 20-50 mg/d in out-patients with OCD Type of the study: Open label, prospective study. Number of patients: 100 patients with OCD Duration of the study: 18-weeks of active treatment, 8-visits: Dose titration: One week of 10mg Four weeks of 20mg After 4 weeks of 20mg treatment- if partial/no response, according to YBOCS score and clinical judgment, dose increase of up to 50mg depending on response, adverse events, patient preference and judgment of the clinician 12 weeks follow up on high dose. Total of 18 weeks of follow-up.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Abarbanel Mental Health Center
Treatments:
Citalopram
Dexetimide
Criteria
Inclusion Criteria:

1. Men and women over 18 years of age

2. DSM IV-TR criteria for OCD

3. OCD associated with most distress or most interference in the patient's life as judged
by the treating physician

4. Yale-Brown Obsessive Compulsive Scale (YBOCS) total score ≥ 16

Exclusion Criteria:

1. Other primary or co-primary psychiatric disorder which is more distressful for the
patient then the OCD, as evaluated by investigator

2. Patients with any history of mania/bipolar disorder

3. Patients using medications which are contraindicated with the use of escitalopram

4. Known contraindication for the use of citalopram or escitalopram.

5. Unable to understand and give informed consent

6. Prominent suicidal ideation (2 points or more in the MADRS "suicidal thoughts" item)

7. Alcohol or substance dependence in the past 6 months

8. Major physical illness

9. Woman currently pregnant or less then 4 weeks after a childbirth, a woman lactating,
or a woman of childbearing potential not using a medically accepted form of
contraception.

10. Liver function abnormality

11. EKG abnormalities