Tocolytic Therapy for Preterm Labor in Multiple Gestation

• Status: Unknown status
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

To compare the tocolytic efficacy oxytocin receptor antagonist (Atosiban) with that of calcium channel blockers (Nifedipine) among women with multiple gestation who present with threatened preterm labor.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tel-Aviv Sourasky Medical Center
• Treatments: Atosiban; Nifedipine; Tocolytic Agents; Vasotocin

Criteria

Inclusion Criteria:

1. Twin pregnancy

2. Gestational age between 24+0 and 32+6 weeks

3. Intact amniotic membranes

4. Threatened preterm labor

5. Age 18-50.

Exclusion Criteria:

1. Rupture of membranes

2. Vaginal bleeding resulting from placenta previa or placental abruption

3. Fever above 38°C

4. Severe preeclampsia

5. Maternal cardiovascular or liver diseases

6. Systolic blood pressure less than 90 mm Hg

7. Known uterine malformation

8. Intrauterine growth restriction below the fifth percentile

9. Non-reassuring fetal status

10. Antepartum diagnosis of major fetal malformations

11. Fetal death

12. Previous tocolytic therapy or Betamethasone treatment