To Study the Efficacy and Safety of Misoprostol by Sublingual Routes for Induction of Labour
Status:
Not yet recruiting
Trial end date:
2021-11-30
Target enrollment:
Participant gender:
Summary
This research is to compare the efficacy and the safety of sublingual misoprostol with
vaginal misoprostol administration for the induction of labour for primigravida at 41 or more
weeks of pregnancy. In routine practice, misoprostol 25µg is used by per vaginal route for
the induction of labour in Bhutan. The misoprostol dose is given repeatedly every 4 hours to
a maximum of 6 dosages. The per vaginal route is found to be very effective and safe for the
induction of labour. But, patient compliance is poor and increasing the risk of neonatal
sepsis since it has to be inserted into vagina every 4 hours. To overcome these problems with
per vaginal route, this study is developed to explore the efficacy and safety of misoprostol
use by sublingual routes for the induction of labour. Misoprostol can be used by sublingual,
oral or per vaginal route as per the findings of the other studies.
If the finding of this study proves sublingual use of misoprostol is safe and efficient for
the induction of labour, the current practice of using misoprostol by vaginal route will be
changed to sublingual route in Bhutan.