To Investigate the Effects of AZD1981 on the QT Interval
Status:
Completed
Trial end date:
2011-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to evaluate the effect of AZD1981 on the electrical
activity of the heart, in particular when the heart muscle is relaxed during a heart beat
cycle. The effect of AZD1981 will be compared to a licensed antibiotic (moxifloxacin) which
is well known to affect the electrical activity of the heart, but this effect is known to be
at levels that are safe at the dose used in this study. The investigators will also compare
the effects of AZD1981 with a "dummy drug" (placebo). The investigators will also be
evaluating how safe and well tolerated AZD1981 is and how much AZD1981 enters the blood
circulation by collecting blood during the study.
Phase:
Phase 1
Details
Lead Sponsor:
AstraZeneca
Treatments:
Moxifloxacin Norgestimate, ethinyl estradiol drug combination