To Evaluate Current Efficacy of Antimalarials Used in Timika, Papua, Indonesia
Status:
Completed
Trial end date:
2004-09-01
Target enrollment:
Participant gender:
Summary
Multidrug resistant strains of P.falciparum and P.vivax are becoming increasingly prevalent
in the Asia Pacific rim. To determine the efficacy of locally recommended antimalarial
protocols in Papua, Indonesia, consecutive patients presenting to a rural clinic were
enrolled into a prospective efficacy study. Patients with uncomplicated falciparum malaria
were treated with chloroquine plus sulfadoxine-pyrimethamine and those with vivax malaria
with chloroquine monotherapy. Patients failing therapy received unsupervised oral quinine +/-
doxycycline for 7 days. Follow-up was continued for 42 days for falciparum malaria and 28
days for vivax malaria.
The study hypothesis was that current recommended antimalarial protocols were no longer
effective.
Phase:
N/A
Details
Lead Sponsor:
Menzies School of Health Research
Collaborators:
National Health and Medical Research Council, Australia National Institute of Health Research and Development, Ministry of Health Republic of Indonesia Wellcome Trust
Treatments:
Chloroquine Chloroquine diphosphate Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine