To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a feasibility study to determine if a sufficient number of patients can be recruited throughout the United Kingdom and whether sufficient endpoints can be generated for a full scale therapeutic trial of anticoagulants versus antiplatelets in acute cervical artery dissection treatment.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St George's, University of London
• Collaborator: The Stroke Association, United Kingdom
• Treatments: Anticoagulants; Aspirin; Calcium heparin; Clopidogrel; Dipyridamole; Heparin; Ticlopidine; Warfarin

Criteria

Inclusion Criteria:

1. Extracranial carotid or vertebral artery dissection with symptom onset within the last 7 days. This includes:

1. Ipsilateral transient ischemic attack or stroke

2. Ipsilateral Horner's syndrome or neck pain with known date of onset.

2. Imaging evidence of definite or probable dissection on MRI/MRA, CTA or ultrasound.

Exclusion Criteria:

1. Intracranial cerebral artery dissection

2. Symptom onset after 7 days

3. Contraindication to either antiplatelet agents or anticoagulation therapy

4. Patient's refusal to consent

5. Patients who are undergoing angiography and stenting or surgery for treatment of their dissection.