To Determine the Effect of GLP1 on Cognitive Function, Brain Glucose Metabolism and Neuroplasticity.
Status:
Completed
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
To test the hypothesis that GLP1 can exert favourable effects on multiple aspects of brain
function. To this purpose, the investigator determine whether chronic increase in GLP1
concentration as it occurs after bariatric surgery (Roux-en- Y Gastric Bypass) is associated
with improvement in:
- cognitive function measured by Mini Mental State Examination (MMSE) and Mental
Deterioration Battery(MDB).
- brain glucose metabolism measured by FDG-CT/PET
- neuroplasticity measure by binocular rivalry and saccadic adaptation tests in morbid
obese subjects. In order to discern the effect of GLP1 irrespective of changes in the
metabolic milieu the investigator will test whether short-term GLP-1 infusion can
modulate the same parameters in healthy subjects.